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研究課題

1·聚磷酸酯高分子生物材料的合成方法學(xué)及性能評(píng)價(jià)；
2·生物可降解納米材料的制備及其細(xì)胞轉(zhuǎn)運(yùn)調(diào)節(jié)和機(jī)制；
3·可注射生物可降解高分子水凝膠的制備及生物醫(yī)用；
4·藥物控制釋放及靶向輸送載體的構(gòu)建及生物學(xué)功效；
5·RNA干擾及siRNA藥物靶向輸送及關(guān)鍵技術(shù)；
6·癌癥基因治療新型傳輸載體、細(xì)胞轉(zhuǎn)運(yùn)機(jī)制及功效；
7·組織工程“人工骨”支架材料及組織工程新方法。 
承擔(dān)科技部“973”項(xiàng)目子課題；國(guó)家自然科學(xué)基金委杰出青年科學(xué)基金；教育部博士點(diǎn)優(yōu)先支持領(lǐng)域課題；科技部“863”課題；“重大新藥創(chuàng)制”科技重大專(zhuān)項(xiàng)課題等。

獲獎(jiǎng)及榮譽(yù)
 
2001 Controlled Release Society-Capsugel Award on Innovative Aspects of Gastrointestinal Drug Absorption and Delivery, Controlled Release Society

論文及專(zhuān)著

1. Xiao CS, Wang YC, Du JZ, Chen XS, Wang J*, Kinetics and Mechanism of 2-Ethoxy-2-oxo-1,3,2-dioxaphospholane Polymerization Initiated by Stannous Octoate, MACROMOLECULES 2006, in press

2. Du JZ, Chen DP, Wang YC, Xiao CS, Lu YJ, Wang J*, Zhang GZ, Synthesis and Micellization of Amphiphilic Brush-Coil Block Copolymer Based on Poly(ε-caprolactone) and PEGylated Polyphosphoester, BIOMACROMOLECULES 2006, 7(6): 1898-1963

3. Chen DP, Wang J*, Synthesis and characterization of block copolymer of polyphosphoester and poly(epsilon-caprolactone), MACROMOLECULES 2006, 39 (2): 473-475

4. Li Q, Wang J, Shahani S, Sun DDN, Sharma B, Elisseeff JH, Leong KW, Biodegradable and photocrosslinkable polyphosphoester hydrogel, BIOMATERIALS 2006, 27 (7): 1027-1034

5. Zou JH, Shi WF, Wang J, Jun B, Encapsulation and controlled release of a hydrophobic drug using a novel nanoparticle-forming hyperbranched polyester, MACROMOLECULAR BIOSCIENCE 2005, 5 (7): 662-668

6. Zhang PC, Wang J, Leong KW, Mao HQ, Ternary complexes comprising polyphosphoramidate gene carriers with different types of charge groups improve transfection efficiency, BIOMACROMOLECULES 2005, 6 (1): 54-60

7. Wan ACA, Mao HQ, Wang S, Phua SH, Lee GP, Pan JS, Lu S, Wang J, Leong KW, Poly(phosphoester) ionomers as tissue-engineering scaffolds, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 2004, 70B (1): 91-102

8. Wang J, Lee IL, Lim WS, Chia SM, Yu H, Leong KW, Mao HQ, Evaluation of collagen and methylated collagen as gene carriers, INTERNATIONAL JOURNAL OF PHARMACEUTICS 2004, 279 (1-2): 115-126

9. Wang J, Gao SJ, Zhang PC, Wang S, Mao MQ, Leong KW, Polyphosphoramidate gene carriers: effect of charge group on gene transfer efficiency, GENE THERAPY 2004, 11 (12): 1001-1010

10. Huang SW, Wang J, Zhang PC, Mao HQ, Zhuo RX, Leong KW, Water-soluble and nonionic polyphosphoester: Synthesis, degradation, biocompatibility and enhancement of gene expression in mouse muscle, BIOMACROMOLECULES 2004, 5 (2): 306-311

11. Wang J, Sun DDN, Shin-ya Y, Leong KW, Stimuli-responsive hydrogel based on poly(propylene phosphate), MACROMOLECULES 2004, 37 (2): 670-672

12. Li Q, Williams CG, Sun DDN, Wang J, Leong K, Elisseeff JH, Photocrosslinkable polysaccharides based on chondroitin sulfate, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH 2004, 68A (1): 28-33

13. Li Y, Wang J, Lee CGL, Wang CY, Gao SJ, Tang GP, Ma YX, Yu H, Mao HQ, Leong KW, Wang S, CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexes, GENE THERAPY 2004, 11 (1): 109-114

14. Lu HF, Lim WS, Wang J, Tang ZQ, Zhang PC, Leong KW, Chia SM, Yu H, Mao HQ, Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance, BIOMATERIALS 2003, 24 (27): 4893-4903

15. Wang J, Huang SW, Zhang PC, Mao HQ, Leong KW, Effect of side-chain structures on gene transfer efficiency of biodegradable cationic polyphosphoesters, INTERNATIONAL JOURNAL OF PHARMACEUTICS 2003, 265 (1-2): 75-84

16. Fang N, Wang J, Mao HQ, Leong KW, Chan V, BHEM-Chol/DOPE liposome induced perturbation of phospholipid bilayer, COLLOIDS AND SURFACES B-BIOINTERFACES 2003, 29 (4): 233-245

17. Zhao Z, Wang J, Mao HQ, Leong KW, Polyphosphoesters in drug and gene delivery

ADVANCED DRUG DELIVERY REVIEWS 2003, 55 (4): 483-499

18. Wang J, Zhang PC, Lu HF, Ma N, Wang S, Mao HQ, Leong KW, New polyphosphoramidate with a spermidine side chain as a gene carrier, JOURNAL OF CONTROLLED RELEASE2002, 83 (1): 157-168

19. Wang J, Zhang PC, Mao HQ, Leong KW, Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier, GENE THERAPY 2002, 9 (18): 1254-1261

20. Wang J, Mao HQ, Leong KW, A novel biodegradable gene carrier based on polyphosphoester, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2001, 123 (38): 9480-9481